Journal article
Common breast cancer susceptibility loci are associated with triple-negative breast cancer
KN Stevens, CM Vachon, AM Lee, S Slager, T Lesnick, C Olswold, PA Fasching, P Miron, D Eccles, JE Carpenter, AK Godwin, C Ambrosone, R Winqvist, H Brauch, MK Schmidt, A Cox, SS Cross, E Sawyer, A Hartmann, MW Beckmann Show all
Cancer Research | AMER ASSOC CANCER RESEARCH | Published : 2011
Abstract
Triple-negative breast cancers are an aggressive subtype of breast cancer with poor survival, but there remains little known about the etiologic factors that promote its initiation and development. Commonly inherited breast cancer risk factors identified through genome-wide association studies display heterogeneity of effect among breast cancer subtypes as defined by the status of estrogen and progesterone receptors. In the Triple Negative Breast Cancer Consortium (TNBCC), 22 common breast cancer susceptibility variants were investigated in 2,980 Caucasian women with triple-negative breast cancer and 4,978 healthy controls. We identified six singlenucleotide polymorphisms, including rs204621..
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Grants
Awarded by Deutsche Krebshilfe e.V.
Awarded by Federal Ministry of Education and Research (BMBF) Germany
Awarded by Australian NHMRC
Awarded by Breast Cancer Campaign
Awarded by Hellenic Cooperative Oncology Group
Awarded by European Union
Awarded by Cancer Research UK
Awarded by "Stichting tegen Kanker"
Awarded by Academy of Finland
Awarded by SPORE
Awarded by Cancer Center Support Grant Shared Resource
Awarded by Dutch Cancer Society
Funding Acknowledgements
[ "The MARIE study was supported by the Deutsche Krebshilfe e.V. grant 70-2892-BR I, the Hamburg Cancer Society, the German Cancer Research Center (DKFZ), and the DNA extraction and genotype work in part by the Federal Ministry of Education and Research (BMBF) Germany grant 01KH0402.", "The GENICA Network was funded by the Federal Ministry of Education and Research (BMBF) Germany grants 01KW9975/5, 01KW9976/8, 01KW9977/0, and 01KW0114, the Robert Bosch Foundation of Medical Research, Stuttgart, Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart, and University Tubingen, Germany (H. Brauch, Christina Justenhoven); Molecular Genetics of Breast Cancer, Deutsches Krebsforschungszentrum (DKFZ), Heidelberg, Germany (U. Hamann); Department of Internal Medicine, Evangelische Kliniken Bonn gGmbH, Johanniter Krankenhaus, Bonn, Germany (Y.-D. Ko, Christian Baisch); Institute of Pathology, Medical Faculty of the University of Bonn, Germany (Hans-Peter Fischer); and Institute for Prevention and Occupational Medicine of the German Social Accident Insurance (IPA), Bochum, Germany (Thomas Bruning, Beate Pesch, Volker Harth, and Sylvia Rabstein).", "The MCCS was supported by Australian NHMRC grants 209057, 251553, and 504711 and infrastructure provided by the Cancer Council Victoria.", "The SBCS was supported by the Breast Cancer Campaign (grant 2004Nov49 to A. Cox) and by Yorkshire Cancer Research core funding.", "This work was supported by the Hellenic Cooperative Oncology Group research grant (HR R_BG/04) and the Greek General Secretary for Research and Technology (GSRT) Program, Research Excellence II, funded at 75% by the European Union.", "P. A. Fasching was partly funded by the Dr. Mildred Scheel Stiftung of the Deutsche Krebshilfe e.V.", "The BBC NCRN study is funded by Cancer Research UK and Breakthrough Breast Cancer and acknowledges NHS funding to the NIHR Biomedical Research Centre and the National Cancer Research Network (NCRN).", "LMBC is supported by European Union Framework Programme 6 Project LSHC-CT-2003-503297 (the Cancerdegradome) and by the \"Stichting tegen Kanker\" (232-2008).", "OBCS was supported by grants and other funding from the Finnish Cancer Foundation, the Sigrid Juselius Foundation, the Academy of Finland, the University of Finland, and Oulu University Hospital.", "SEARCH was supported by Cancer Research UK grants C1287/A7497, C490/A11021, C1287/A10118, and C1287/A5260.", "The HEBCS study has been financially supported by the Helsinki University Central Hospital Research Fund, Academy of Finland (132473), the Finnish Cancer Society, and the Sigrid Juselius Foundation.", "A.K. Godwin was funded by SPORE P-50CA83638, U01CA69631, 5U01CA113916, and the Eileen Stein Jacoby Fund.", "Data and samples were obtained from the RPCI Data Bank and BioRepository (DBBR; ref. 40), a Cancer Center Support Grant Shared Resource (P30 CA016056-32).", "The SKKDKFZS study was supported by the Deutsches Krebsforschungszentrum.", "E. Sawyer is funded by the National Institute for Health Research (NIHR) Comprehensive Biomedical Research Centre, Guy's & St. Thomas' NHS Foundation Trust in partnership with King's College London and King's College Hospital NHS Foundation Trust.", "The ABCTB is generously supported by the National Health and Medical Research Council of Australia, The Cancer Institute NSW, and the National Breast Cancer Foundation.", "M.K. Schmidt was funded by the Dutch Cancer Society grant 2009-4363." ]